|
|||||
|
|
Cysteinyl-tRNA formation and prolyl-tRNA synthetase |
|
| Authors: | Jacquin-Becker Clarisse Ahel Ivan Ambrogelly Alexandre Ruan Benfang Söll Dieter Stathopoulos Constantinos |
| Affiliation: | Department of Molecular Biophysics and Biochemistry, Yale University, P.O. Box 208114, 266 Whitney Avenue, New Haven, CT 06520-8114, USA. |
| Abstract: | Aminoacyl-tRNA (AA-tRNA) formation is a key step in protein biosynthesis. This reaction is catalyzed with remarkable accuracy by the AA-tRNA synthetases, a family of 20 evolutionarily conserved enzymes. The lack of cysteinyl-tRNA (Cys-tRNA) synthetase in some archaea gave rise to the discovery of the archaeal prolyl-tRNA (Pro-tRNA) synthetase, an enzyme capable of synthesizing Pro-tRNA and Cys-tRNA. Here we review our current knowledge of this fascinating process. |
| Keywords: | Aminoacyl-tRNA synthetase Prolyl-tRNA synthetase Amino acid activation tRNA Translation |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |