Synthesis of radiolabeled biphenylsulfonamide matrix metalloproteinase inhibitors as new potential PET cancer imaging agents |
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| Authors: | Fei Xiangshu Zheng Qi Huang Liu Xuan Wang Ji Quan Sun Hui Bin Mock Bruce H Stone K Lee Miller Kathy D Sledge George W Hutchins Gary D |
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| Institution: | Department of Radiology, Indiana University School of Medicine, IN 46202, Indianapolis, USA. |
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| Abstract: | Novel matrix metalloproteinase (MMP) inhibitor radiotracers, (S)-3-methyl-2-(2',3',4'-methoxybiphenyl-4-sulfonylamino)-butyric acid (11)C]methyl ester (1a-c), (S)-3-methyl-2-(2',3',4'-fluorobiphenyl-4-sulfonylamino)-butyric acid (11)C]methyl ester (1d-f), and (S)-3-methyl-2-(4'-nitrobiphenyl-4-sulfonylamino)-butyric acid (11)C]methyl ester (1g), a series of substituted biphenylsulfonamide derivatives, have been synthesized for evaluation as new potential positron emission tomography (PET) cancer imaging agents. |
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