Decomposition of overlapping protein complexes: A graph theoretical method for analyzing static and dynamic protein associations |
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| Authors: | Elena Zotenko Katia S Guimarães Raja Jothi Teresa M Przytycka |
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| Institution: | (1) National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, USA;(2) Department of Computer Science, University of Maryland, College Park, USA;(3) Center of Informatics, Federal University of Pernambuco, Recife, Brazil |
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| Abstract: | Background Most cellular processes are carried out by multi-protein complexes, groups of proteins that bind together to perform a specific
task. Some proteins form stable complexes, while other proteins form transient associations and are part of several complexes
at different stages of a cellular process. A better understanding of this higher-order organization of proteins into overlapping
complexes is an important step towards unveiling functional and evolutionary mechanisms behind biological networks. |
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