类风湿性关节炎伴间质性肺病中肿瘤标志物对肺功能的影响分析

目的：探究类风湿性关节炎伴间质性肺病中肿瘤标志物对肺功能的影响。方法：选取2011年3月至2013年3月我院收治的类风湿性关节炎患者88例，根据其是否伴有ILD，分为RA组53例和RA-ILD组35例。检测两组肺功能指标用力肺活量（FVC）、1s用力呼气容积（FEV1）、最大通气量百分比（MVV）、一氧化碳弥散量（DLCO），肿瘤标志物癌胚抗原CEA、癌抗原125（CA125）、癌抗原199（CA199）及抗环胍氨酸肽抗体（抗CCP抗体）的值，并利用统计学方法分析肿瘤标记物与肺功能指标、抗CCP抗体的相关性。结果：RA．ILD组FVC、FEV1、MVV、DLCO均比RA组低，CEA、CA125、CA199均比RA组高，结果比较差异显著具有统计学意义（P〈0．05）。但两组抗CCP抗体含量相比却无明显差异，不具有统计学意义（P〉0．05）。相关性分析显示，CEA与FVC、FEV1、MVV、DLCO呈负相关（P〈0．05），而CA125、CA199却与肺功能指标无相关性，CEA、CA125、CA199与抗CCP抗体均无相关性（P〉0．05）。结论：RA-ILD的肺功能指标均有明显下降，而肿瘤标志物表达水平却明显增高，CEA对肺功能损害影响较大，却与关节损害的关系不大，这为临床对类风湿性关节炎伴间质性肺病早诊断、早治疗提供了依据。

The Influence Of Tumor Markers in Rheumatoid Arthritis with Interstitial Lung Disease on Lung Function

Objective： To observe the influence of tumor markers in rheumatoid arthritis with interstitial lung disease on lung func- tion. Methods： We select 88 rheumatoid arthritis patients accepted by our hospital from March 2011 to March 2013, in accordance with its associated ILD or not, were divided into RA group （53 cases） and RA-ILD group （35 cases）, we detectedlungfunctionoftwogroups, in- cluding forced vital capacity （FVC）, 1 s forced expiratory volume （FEV1）, percentage of maximum voluntary ventilation （MVV）, carbon monoxide diffusing capacity （DLCO）. And we detectedtumor markers, including carcinoembryonic antigen （CEA）, cancer antigen 125 （CA125）, cancer antigen 199 （CA199） and anti-cyclic citrulline peptide antibodies （anti-CCP） values, and then the statistical methods were used to analyse the correlation of tumor markers with lung function and anti-CCP antibody. Results： The FVC, FEV1, MVV and D1- CO of RA-ILD group were less than that of the RA grOup and the CEA, CA125, CA199 were higher, the results were statistically signifi- cant （P〈0.05）. theanti-CCPantibodylevels ofthetwogroups were comparivel levels with no significant difference （P〉0.05）. Correlation analysis showed that CEA and FVC, FEV1, MVV, DLCO was negatively correlated （P 〈0.05）, CA125, CA199 with lung function and CEA, CA125, CA199 with anti-CCP antibodies had no correlation （P〉 0.05）. Conclusion： The lung function indexes of RA-ILD are sig- nificantly decreased and tumor marker expression levels are significantly higher, CEA had greater impact on lung function damage, but it has little to do with the joint damage. It provides the basis for the clinical to give early diagnosis and early treatment to rheumatoid arthri- tis with interstitial lung dis- ease.