MHC multimerization, antigen expression and the induction of APC amnesia in the developing immune response |
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| Authors: | Lake R A Robinson B W Hayball J D |
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| Affiliation: | University Department of Medicine, Queen Elizabeth II Medical School, Nedlands, Perth, Australia. rlake@cyllene.uwa.edu.au |
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| Abstract: | Class II multimer formation is an important event in immune recognition. Not only is multimerization a prerequisite for T cell activation, but it is a signal to APC. In the present article, we propose that multimerization can result in the specific removal of ligand complexes from the cell surface of the APC, an event which may influence the overall pattern of T cell reactivity. |
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