口腔微生物耐氟机制的研究进展

氟化物一直被当作一种有效的抗龋药物广泛应用,但长期使用氟化物可能会导致耐氟菌株的出现,使其通过表型适应或基因型改变对氟产生抗性,降低氟化物防龋效果,且长期氟干扰可能引起口腔微生态失衡,从而诱发疾病。鉴于氟与口腔疾病防治的密切关系,以及口腔微生物稳态对于口腔乃至全身健康的重要作用,本文就口腔微生物耐氟机制的研究进展作一综述。

Research progress in fluoride resistance mechanism of oral microorganism

Fluoride had been widely used as an effective anti-caries agent for decades. However, the long-term use of fluoride might lead to the emergence of fluoride-resistant strains. The fluoride-resistant ability of microorganism could be induced by the phenotypic adaptation or genotypic changes, subsequently, the anti-caries effect of fluoride might decrease. Besides, long-term fluoride interference might disturb the balance of oral micro-ecosystem, leading to associated oral diseases. In general, fluoride played an important role in the prevention and treatment of oral diseases, while oral microbial homeostasis was crucial for oral and systemic health. Therefore, in this paper we reviewed the research progress on the fluoride-resistant mechanism of oral microorganisms.