Proteolytic modification of staphylokinase |
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| Affiliation: | 1. Department of Infectious Diseases, Azienda Ospedaliera dei Colli, Naples, Italy;2. Institute of Life Sciences, Scuola Superiore Sant''Anna, Pisa, Italy;3. Emergency Medicine Department, University Hospital of Pisa, Italy;4. Fondazione Toscana Gabriele Monasterio, Pisa, Italy;5. Emergency Medicine Department, Livorno Hospital, Livorno, Italy;6. Institute of Infectious Diseases, Università Cattolica del Sacro Cuore, Rome, Italy;7. Fondazione Policlinico Universatario A. Gemelli IRCSS, UOC Infectious Diseases, Rome, Italy;8. Section of Infectious Diseases, Department of Medicine, University of Perugia, Perugia, Italy;9. Section of Infectious Diseases, Department of Medicine, University of Perugia, Terni, Italy;10. Infectious and Tropical Diseases Unit, AORN S. Anna e S. Sebastiano, Caserta, Italy;11. UOSD Advanced Techniques in Cardiosurgery, Monaldi Hospital, AORN dei Colli, Naples, Italy;12. Fondazione Toscana Gabriele Monasterio, Massa, Italy;1. Institute of Physical Chemistry of the Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland;2. Nencki Institute of Experimental Biology of the Polish Academy of Sciences, 3 Pasteur Street, 02-093 Warsaw, Poland;3. State Key Laboratory of Medicinal Chemical Biology, Nankai University, China |
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| Abstract: | ![]()
There are three types of staphylokinase of different isoelectric points (6.7, 6.1 and 5.7). Staphylokinase of pI 6.7 was converted to that of pI 6.1 and then to that of pI 5.7 by the treatment with trypsin.Heterogeneity of staphylokinase might be the result of post-translational modification by proteolytic enzyme. |
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