Predictions of native American population structure using linguistic covariates in a hidden regression framework |
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Authors: | Jay Flora François Olivier Blum Michael G B |
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Institution: | Laboratoire des Techniques de l'Ingénierie Médicale et de la Complexité, Equipe Biologie Computationnelle et Mathématique, Faculté de Médecine, Université Joseph Fourier, Grenoble, Centre National de la Recherche Scientifique, La Tronche, France. |
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Abstract: | BackgroundThe mainland of the Americas is home to a remarkable diversity of languages,
and the relationships between genes and languages have attracted
considerable attention in the past. Here we investigate to which extent
geography and languages can predict the genetic structure of Native American
populations.Methodology/Principal FindingsOur approach is based on a Bayesian latent cluster regression model in which
cluster membership is explained by geographic and linguistic covariates.
After correcting for geographic effects, we find that the inclusion of
linguistic information improves the prediction of individual membership to
genetic clusters. We further compare the predictive power of
Greenberg''s and The Ethnologue classifications of
Amerindian languages. We report that The Ethnologue
classification provides a better genetic proxy than Greenberg''s
classification at the stock and at the group levels. Although high
predictive values can be achieved from The Ethnologue
classification, we nevertheless emphasize that Choco, Chibchan and Tupi
linguistic families do not exhibit a univocal correspondence with genetic
clusters.Conclusions/SignificanceThe Bayesian latent class regression model described here is efficient at
predicting population genetic structure using geographic and linguistic
information in Native American populations. |
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