Essential fructosuria: increased levels of fructose 3-phosphate in erythrocytes. |
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Authors: | A Petersen B Steinmann R Gitzelmann |
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Institution: | Department of Clinical Biochemistry, State University Hospital (Rigshospitalet), Copenhagen, Denmark. |
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Abstract: | Erythrocytes of 3 adult siblings with essential fructosuria contained 45-200 mumol/l fructose 3-phosphate (Fru-3-P), i.e. 3-15 times the concentration in normal controls. Sorbitol 3-phosphate was also increased, but to a lesser degree. An oral load with 50 g of fructose produced an additional 40 mumol/l increase of erythrocyte Fru-3-P after 5 h. The rate of Fru-3-P formation by red cells in vitro was normal. HbA1 and HbA1c were normal. The suspected pathogenetic role of Fru-3-P in diabetic complications is questioned. |
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