Mouse intestinal innate immune responses altered by enterotoxigenic Escherichia coli (ETEC) infection |
| |
| Institution: | 1. Laboratory of Animal Nutrition and Health and Key Laboratory of Agro-Ecology, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Changsha, Hunan 410125, PR China;2. Division of Immunology, Virginia-Maryland Regional College of Veterinary Medicine, Maryland Pathogen Research Institute, University of Maryland, College Park, MD 20742, USA;3. Department of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS 66506, USA;1. Institute of Agricultural Sciences, ETH Zurich, 8092 Zurich, Switzerland;2. Department of Farm Animals, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland;3. Institute of Genetics, Vetsuisse Faculty, University of Berne, 3012 Berne, Switzerland;1. College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, China;2. Laboratory Animal Center, Jilin University, Changchun 130062, China;1. College of Veterinary Medicine, South China Agricultural University, Wushan Road, Tianhe district, Guangzhou 510642, China;2. State Key Laboratory of Livestock and Poultry Breeding, Ministry of Agriculture and Rural Affairs Key Laboratory of Animal Nutrition and Feed Science in South China, Guangdong Key Laboratory of Animal Breeding and Nutrition, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, 1 Dafeng 1st Street, Guangzhou 510640, China;1. Institute of Subtropical Agriculture, Chinese Academy of Sciences, Research Center of Healthy Breeding Livestock & Poultry, Hunan Engineering & Research Center of Animal & Poultry Science, Key Lab Agro-ecology Processing Subtropical Region, Scientific Observational and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha, Hunan, People''s Republic of China;2. Department of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, USA;1. University of Gothenburg Vaccine Research Institute (GUVAX), Dept. of Microbiology and Immunology, University of Gothenburg, Box 435, 405 30 Gothenburg, Sweden;2. PATH, 455 Massachusetts Ave, NW, WA, DC 20001, USA;3. Scandinavian Biopharma, Gunnar Asplunds allé 16, 171 63 Solna, Sweden;4. Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA;5. Clinical Trial Center, Sahlgrenska University Hospital, Gröna stråket 12, 413 45 Gothenburg, Sweden;6. Centre for Applied Biostatistics, Sahlgrenska Academy, University of Gothenburg, Box 414, 405 30 Gothenburg, Sweden |
| |
| Abstract: | Enterotoxigenic Escherichia coli (ETEC) is an important cause of human and porcine morbidity and mortality. The current study was conducted to identify intestinal immunity that is altered in a mouse model of ETEC infection. Innate immune responses and inflammation were analyzed. The activation of signal transduction pathways, including toll like receptor 4 (TLR-4)-nuclear factor kappa B (NF-κB) and mitogen-activated protein kinases (MAPK), was analyzed using immunoblotting and PCR array analyses. We found that ETEC infection promoted the expression of pro-inflammatory cytokines through the activation of the NF-κB and MAPK pathways. Meanwhile, ETEC infection affected sIgA transportation and Paneth cell function. These data improve our understanding of how ETEC causes disease in animals. |
| |
| Keywords: | ETEC Paneth cell Innate immunity NF-κB MAPK |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
