The interplay between central metabolism and innate immune responses |
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| Affiliation: | 1. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children''s Medical Center, Tehran University of Medical Sciences, Tehran, Iran;2. Molecular Immunology Research Center, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran;3. Department of Infection and Immunity, School of Medicine and Biomedical Sciences, The University of Sheffield, Sheffield, UK;1. School of Life Sciences, Faculty of Science, Engineering and Computing, Kingston University, Kingston upon Thames, Surrey KT1 2EE, United Kingdom;2. Faculty of Medicine and Medical Sciences, University of Balamand, 33 Amioun, Al Kurah, Lebanon;3. Division of Clinical Sciences, St George’s, University of London, London SW170RE, United Kingdom;4. Department of Academic Surgery, Royal Marsden Hospital, London SW3 6JJ, United Kingdom;5. The London Clinic, London W1G 6JA, United Kingdom |
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| Abstract: | A growing body of recent studies bring into light an important cross-talk between immune response and metabolism not only at the level of the organism as a whole, but also at the level of the individual cells. Cellular bioenergetics functions not only as a power plant to fuel up the cells, but the intermediate metabolites are shown to play an important role to modulate cellular responses. It is especially the pathways through which a cell metabolizes glucose that have been recently shown to influence both innate and adaptive immune responses, with oxidative phosphorylation used by resting or tolerant cells, while aerobic glycolysis (also termed ‘Warburg effect’) fueling activated cells. In this review we will address how the center metabolism shifts upon activation in the innate immune cells and how the intermediate metabolites modulate the function of immune cells. |
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| Keywords: | Immunometabolism Cytokines Glycolysis Oxidative phosphorylation Innate immunity |
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