Exosomal Transfer of Vasorin Expressed in Hepatocellular Carcinoma Cells Promotes Migration of Human Umbilical Vein Endothelial Cells |
| |
| Authors: | Aixue Huang Jie Dong Shaohua Li Chaonan Wang Hongmei Ding Hui Li Xueting Su Xingfeng Ge Leqiao Sun Chenjun Bai Xuelian Shen Tao Fang Jie Li Ningsheng Shao |
| |
| Affiliation: | Beijing Institute of Basic Medical Sciences, Beijing 100850, China |
| |
| Abstract: | Vasorin (VASN) is a type I transmembrane protein that plays important roles in tumor development and vasculogenesis. In this paper, we showed that VASN could be a key mediator of communication between tumor cells and endothelial cells. We confirmed for the first time that HepG2-derived VASN can be transferred to human umbilical vein endothelial cells (HUVECs) via receptor mediated endocytosis of exosomes, at least in part through HSPGs. The HepG2-derived VASN containing exosomes promote migration of recipient HUVECs cells. Our results identify a novel pathway by which a functional protein expressed in tumor cells affects the biological fate of endothelial cells via exosomes. |
| |
| Keywords: | Vasorin exosomes endocytosis angiogenesis tumor metastasis |
|
