The effect of bio-converted polyunsaturated fatty acids on the oxidation of TAG containing highly unsaturated fatty acids |
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| Authors: | Young-Mi Kim Geon-Ho Lee Young-Geun Yeo In-Hwan Kim Kazuo Miyashita Ching T. Hou Sun-Chul Kang Hak-Ryul Kim |
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| Affiliation: | (1) Department of Animal Science and Biotechnology, Kyungpook National University, Daegu, 702-701, Korea;(2) Department of Food and Nutrition, College of Health Sciences, Korea University, Seoul, Korea;(3) Laboratory of Biofunctional Material Chemistry, Division of Marine Bioscience, Graduate School of Fisheries Sciences, Hokkaido University, Hakodate 041-8611, Japan;(4) Microbial Genomic and Bioprocessing Research Unit, National Center for Agricultural Utilization Research, ARS, USDA, Peoria, IL, USA;(5) Division of Food, Biological and Chemical Engineering, Daegu University, Daegu, 712-714, Korea |
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| Abstract: | Microbial modification of vegetable fatty acids can often lead to special changes in their structure and in biological function. A bacterial strain, Pseudomonas aeruginosa PR3, is known to carry out multiple hydroxylations on polyunsaturated fatty acids containing 1,4-cis, cis diene structural units, resulting in antibacterial activity. In this paper, in an effort to understand the overall mechanism involved in the varied biological functions of the complicated metabolites of bio-converted polyunsaturated fatty acids, we performed bioconversion of several polyunsaturated fatty acids using PR3, and determined their oxidative activities against fish oil. Bio-converted linoleic acid, eicosapentanoic acid, and docosahexanoic acid promoted effectively oxidation of fish oil. It is assumed that this oxidative effect could plausibly play an important role in the antimicrobial function of these bio-converted fatty acids. |
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| Keywords: | Oxidation Pseudomonas aeruginosa Bio-conversion Hydroxy fatty acid |
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