The metabolic conversion of folic acid and citrovorum factor to a diazotizable amine期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

The metabolic conversion of folic acid and citrovorum factor to a diazotizable amine

Authors:	ALLEN B DAY P L DINNING J S SIME J T WORK P S

Affiliation:	1. Key Laboratory of Public Health Safety of Hebei Province, College of Public Health, Hebei University, Baoding, 071002, China;2. Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, College of Pharmaceutical Sciences, Hebei University, Baoding, 071002, China;1. College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China;2. Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center, Jieyang 515200, China;1. Centre National de la Recherche Scientifique, Laboratoire de Chimie des Polymères Organiques, UMR 5629, F-33607 Pessac Cedex, France;2. Université de Bordeaux, Laboratoire de Chimie des Polymères Organiques, ENSCBP, Bâtiment A, 16, Avenue Pey-Berland, F-33607 Pessac Cedex, France;3. ITERG, 11 rue Gaspard Monge, Parc Industriel, Pessac Cedex F-33600, France

Abstract:	Incubation of pteroylglutamic acid (PGA) (folic acid) with liver slices leads to the formation of a diazotizable amine; this reaction is inhibited by aminopterin. Incubation of synthetic citrovorum factor (CF) with liver homogenate results in amine formation, and the reaction is not inhibited by aminopterin. The data indicate that PGA is converted to CF which in turn is cleaved to a diazotizable amine. This cleavage reaction is strongly inhibited by ascorbic acid.The urinary excretion of diazotizable amine by rats is proportional to the dose of injected PGA or CF. The magnitude of the amine excretion suggests that cleavage to a diazotizable amine is a pathway of importance for the metabolic disposal of CF.

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