Effect of anthracycline antibiotics on the reconstituted mitochondrial tricarboxylate carrier |
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| Authors: | I Stipani M I Capalbo V Zara |
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| Affiliation: | Department of Pharmaco-Biology, University of Bari, Italy. |
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| Abstract: | The effect of anthracycline antibiotics on the activity of the partially purified and reconstituted tricarboxylate carrier system of the rat liver mitochondria was studied. It was found that the citrate/citrate exchange activity is inhibited by Br-daunomycin and with less potency by doxorubicin, daunomycin, epirubicin and idarubicin. The inhibition of the citrate transport activity is concentration and time-dependent. Cardiolipin protects against the inhibition by Br-daunomycin and the reconstituted citrate transport activity depends upon the ratio of cardiolipin/Br-daunomycin. |
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