Cytokines and chronic liver disease |
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Authors: | Fainboim Leonardo Cherñavsky Alejandra Paladino Natalia Flores Ana C Arruvito Lourdes |
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Institution: | Hospital de Clínicas José de San Martín, and Departamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, Argentina. lfainboim@hospitaldeclinicas.uba.ar |
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Abstract: | From an immunological point of view, the healthy liver has been usually associated with the phenomenon of tolerance. A microenvironment of regulatory cytokines produced by liver Kuppfer cells and liver sinusoidal endothelial cells has contributed, together with resident dendritic cells, to generate a tolerogenic environment in this tissue. In this review we discussed the intrahepatic responses to different sorts of liver injury, such as hepatotrophic viruses, alcohol or putative self-antigens. In each case we analyzed the impact of different cytokines in the clinical outcome of the different pathological situations. |
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