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Epstein-Barr virus-encoded latent membrane protein 1 modulates cyclin D1 by c-Jun/Jun B heterodimers |
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| Authors: | Xin?Song Yongguang?Tao Liang?Zeng Jing?Yang Faqing?Tang Leo?M?Lee Jianping?Gong Qiao?Wu |
| Institution: | 1. Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha 410078, China 2. Laboratory of Molecular Technology SAIC-Frederick, National Cancer Institute P.O. Box B, Frederick, MD 21702, USA 3. Molecular Medical Center, Tongji Hospital, Tongji Medical University, Wuhan 430030, China 4. Key Laboratory of the Ministry of Education for Cell Biology, and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, China |
| Abstract: | In our recent studies, we found that LMP1 encoded by Epstein-Barr virus could accelerate the formation of active c-Jun/Jun B heterodimer. We studied the regulation of cyclinD1 by c-Jun/Jun B heterodimers by laser scanning confocal influorescence microscopy, Western blot, luciferase activity assay, super-EMSA and flow cytometry in the Tet-on-LMP1 HNE2 cell line, in which LMP1 expression was regulated by Tet-on system. c-Jun/Jun B heterodimers induced by LMP1 could up regulate cyclin D1 promoter activity and expression. Overexpression of cyclinD1 accelerated the progression of cell cycle. |
| Keywords: | latent membrane protein1 c-Jun Jun B heterodimer cyclin D1 cell cycle |
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