Regulation of sterol biosynthesis inSaccharomyces cerevisiae |
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Authors: | B Běhalová M Bláhová V Běhal |
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Institution: | (1) Institute of Microbiology, Academy of Sciences of the Czech Republic, 142 20 Prague 4, Czech Republic |
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Abstract: | Sterol synthesis inSaccharomyces cerevisiae was primarily controlled by the growth rate. At low specific growth rates the intermediates of ergosterol biosynthesis prevailed
in cells. At the same time, the total sterol content reached about 6% of dry matter whereas the content of ergosterol was
only 2–2.5%, which seems to be the maximum value forS. cerevisiae. After esterification with fatty acids these sterol intermediates are stored in lipid globules together with reserve triacylglycerols.
The sporulatingS. cerevisiae cells contained 3.5% sterols and 1.5% ergosterol of dry matter. |
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