| 蛇毒类激肽释放酶的研究进展 |
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| 引用本文： | 周 茜,许文涛,黄昆仑,等. 蛇毒类激肽释放酶的研究进展[J]. 生物学杂志, 2014, 0(2): 73-76 |
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| 作者姓名： | 周 茜 许文涛 黄昆仑 等 |
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| 作者单位： | [1]中国农业大学食品科学与营养工程学院,北京100083 [2]农业部转基因生物食用安全监督检验测试中心（北京）,北京100083 [3]北京赛升药业股份有限公司,北京100176 |
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| 摘 要： | 蛇毒丝氨酸蛋白酶是蛇毒中一类丰富的蛋白水解酶，具有重要的临床应用价值。其中一种丝氨酸蛋白酶一类激肽释放酶，作用于激肽原释放激肽，引起血管舒张，改善微循环，从而逐渐受到关注。对蛇毒中类激肽释放酶的分布、分离制备、生化性质、结构研究和药效研究等方面进行了综述，同时指出了目前存在的问题及今后的发展方向，以期为进一步的基础研究提供理论基础。
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| 关 键 词： | 蛇毒 类激肽释放酶 性质 结构 功能 |
Progress on kallikrein-like enzyme in snake venoms |
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| ZHOU Qian,XU Wen-tao,＇,HUANG Kun-lun,＇,LUO Yun-bo＇,MA Biao. Progress on kallikrein-like enzyme in snake venoms[J]. Journal of Biology, 2014, 0(2): 73-76 |
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| Authors: | ZHOU Qian XU Wen-tao ＇ HUANG Kun-lun ＇ LUO Yun-bo＇ MA Biao |
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| Affiliation: | 3 ( 1. College of Food Science and Nutrition Engineering, China Agricultural University, Beijing 100083 ; 2. The Supervision, Inspection＆Testing Center of Genetically Modified Food Safety, Ministry of Agriculture, Beijing 100083;3. Saisheng Pharmaceutical Company, Beijing 100176, China) |
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| Abstract: | Serine proteinase is a class of abundant proteolytic enzymes in snake venom. It has important clinical practical value. Kal- likrein-like enzyme, a kind of serine proteinase acting on kininogen releasing bradykinin to cause vasodilation and improvment of micro- circulation, was focused on more and more. The paper described the distribution, separation and preparation, biochemical properties, structure and pharmacology study of the kallikrein-like enzyme from snake venoms, pointed out the current problems and future devel- opment and provided the basic theoretical for the future development. |
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| Keywords: | snake venom kallikrein-like enzyme character structure function |
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