| 响应面设计法优化仙鹤草总多酚的超声提取工艺 |
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| 引用本文： | 徐秀泉,李峰,汤建,许源.响应面设计法优化仙鹤草总多酚的超声提取工艺[J].天然产物研究与开发,2012,24(1):114-117. |
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| 作者姓名： | 徐秀泉 李峰 汤建 许源 |
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| 作者单位： | 1. 江苏大学药学院,镇江,212013
2. 江苏大学附属医院,镇江,212001 |
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| 基金项目： | 镇江市社会发展项目(SH2010033) |
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| 摘 要： | 在单因素实验的基础上,采用响应面分析法对影响超声辅助提取仙鹤草总多酚得率的主要因素(超声温度、料液比和乙醇浓度)进行优化,建立了影响因素与总多酚之间的函数关系。获得最佳工艺条件为:71%乙醇,料液比1∶24,超声提取温度60℃,提取时间20 min。在此最佳条件下,总多酚得率为3.56%,试验结果与模型预测值相符。
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| 关 键 词： | 仙鹤草 总多酚 超声提取 响应面设计法 |
Optimization of Ultrasonic-assisted Extraction of Total Polyphenols from Agrimonia pilosa Ledeb.by Response Surface Methodology |
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| XU Xiu-quan
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LI Feng
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TANG Jian
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XU Yuan.Optimization of Ultrasonic-assisted Extraction of Total Polyphenols from Agrimonia pilosa Ledeb.by Response Surface Methodology[J].Natural Product Research and Development,2012,24(1):114-117. |
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| Authors: | XU Xiu-quan LI Feng TANG Jian XU Yuan |
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| Institution: | 1College of Pharmacy,Jiangsu University,Zhenjiang 212013,China; 2Affiliated Hospital of Jiangsu University,Zhenjiang 212001,China |
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| Abstract: | Response surface methodology(RSM) was used to optimize ultrasonic-assisted extraction for total polyphenols from Agrimonia pilosa Ledeb.based on single-factor experiment.The main factors extraction temperature,liquid-material ratio and ethanol concentration were determined.The relationship between influencing factors and response values was established.The optimum extraction conditions were as follows:the extracting solvent was 71% ethanol,solid-liquid ratio was 1∶ 24,extracting temperature was 60 ℃,and extracting time was 20 min.Under these conditions,the maximal yield of total polyphenols reached 3.56%,which was well matched with the predicted content. |
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| Keywords: | Agrimonia pilosa Ledeb total polyphenols ultrasonic-assisted extraction response surface methodology |
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