General methods of sequence comparison |
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| Authors: | Michael S. Waterman |
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| Affiliation: | (1) Departments of Mathematics, University of Southern California, 90089-1113 Los Angeles, CA, U.S.A.;(2) Department of Molecular Biology, University of Southern California, 90089-1113 Los Angeles, CA, U.S.A. |
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| Abstract: | Mathematical methods for comparison of nucleic acid sequences are reviewed. There are two major methods of sequence comparison: dynamic programming and a method referred to here as the regions method. The problem types discussed are comparison of two sequences, location of long matching segments, efficient database searches and comparison of several sequences. This work was supported by a grant from the System Development Foundation. |
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