| 血管内皮生长因子在大鼠骨折骨痂中的表达及意义(简报) |
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| 引用本文： | 李长有,梁德勇,范广宇,宋今丹.血管内皮生长因子在大鼠骨折骨痂中的表达及意义(简报)[J].分子细胞生物学报,2005,38(4):359-362. |
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| 作者姓名： | 李长有 梁德勇 范广宇 宋今丹 |
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| 作者单位： | 中国医科大学附属第一医院骨科，中国医科大学附属第一医院骨科，中国医科大学附属第一医院骨科，中国医科大学卫生部细胞生物学重点实验室 沈阳 110001，沈阳 110001，沈阳 110001，沈阳 110001 |
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| 摘 要： | 骨折愈合是一个独特的多步骤过程,最终可导致正常的骨的解剖和骨的功能的恢复,而不像其他组织修复过程往往最终以瘢痕组织结束。骨折后形成大量修复性骨痂组织,包绕骨折部位。骨痂中存在两种骨形成方式:即膜内化骨和软骨内化骨。系统激素和局部生长因子参与调节骨折愈合过程中的膜内化骨、软骨形成和软骨内化骨。在软骨性骨痂的形成与吸收、骨性骨痂的形成与重塑的动态过程中,新生血管的形成起重要作用。在众多的调节
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| 关 键 词： | 骨折 骨痂 血管内皮生长因子 大鼠 |
| 修稿时间： | 2004年10月18 |
THE EXPRESSION OF VEGF IN RAT FRACTURE REPARATIVE CALLUS |
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| LI Chang You,LIANG De Yong,FAN Guang Yu,SONG Jin Dan.THE EXPRESSION OF VEGF IN RAT FRACTURE REPARATIVE CALLUS[J].Journal of Molecular Cell Biology,2005,38(4):359-362. |
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| Authors: | LI Chang You LIANG De Yong FAN Guang Yu SONG Jin Dan |
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| Institution: | LI Chang You,LIANG De Yong,FAN Guang Yu,SONG Jin Dan Department of Orthopaedic Surgery,1st Hospital,China Medical University,Shenyang 110001,China Key Lab of Cell Biology,Ministry of Health of China,Department of Cell Biology,China Medical University,Shenyang 110001,China |
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| Abstract: | The present study has determined the histological changes, VEGF (Vascular en- dothelial growth factor) mRNA alternative expressions and VEGF mRNA levels in chondrogenic- callus, osteogenic-callus and total callus by histology, RT-PCR and Northern blot during rat frac- ture repair. The results showed that the cellular events of intramembranous ossification, chodrogen- esis and endochondral ossification appeared in the callus simultaneously and sequentially. The VEGF mRNAs were expressed in the osteogenic-callus and the chondrogenic-callus, and the strongest expressions were VEGF_(120) and VEGF_(164) mRNA. The VEGF mRNA levels in the total cal- lus increased with time after fracture. Take together, these findings suggest that osteogenesis-de- rived VEGF may play a potential role to modulate the differentiation process of osteogenic and chondrogenic cells during fracture repair. |
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| Keywords: | Fracture Callus VEGF Rat |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
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