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PVT1在恶性肿瘤发生发展中的作用及机制
引用本文：何 奕,魏 芳,张姗姗,龚朝建,郭 灿,李夏雨,李小玲,周 鸣,熊 炜,李桂源,曾朝阳,石 磊.PVT1在恶性肿瘤发生发展中的作用及机制[J].生物化学与生物物理进展,2017,44(11):981-989.
作者姓名：何 奕  魏 芳  张姗姗  龚朝建  郭 灿  李夏雨  李小玲  周 鸣  熊 炜  李桂源  曾朝阳  石 磊
作者单位：中南大学湘雅医学院附属肿瘤医院，湖南省肿瘤医院，长沙 410013；中南大学肿瘤研究所，卫生部癌变原理重点实验室，长沙 410078；中南大学湘雅医院，教育部癌变与侵袭原理重点实验室，长沙 410078,中南大学湘雅医学院附属肿瘤医院，湖南省肿瘤医院，长沙 410013；中南大学肿瘤研究所，卫生部癌变原理重点实验室，长沙 410078；中南大学湘雅医院，教育部癌变与侵袭原理重点实验室，长沙 410078,中南大学湘雅医院，教育部癌变与侵袭原理重点实验室，长沙 410078,中南大学肿瘤研究所，卫生部癌变原理重点实验室，长沙 410078；中南大学湘雅二医院，长沙 410011,中南大学肿瘤研究所，卫生部癌变原理重点实验室，长沙 410078；中南大学湘雅医院，教育部癌变与侵袭原理重点实验室，长沙 410078,中南大学湘雅三医院，湖南省非可控性炎症与肿瘤重点实验室，长沙 410013,中南大学湘雅医学院附属肿瘤医院，湖南省肿瘤医院，长沙 410013；中南大学肿瘤研究所，卫生部癌变原理重点实验室，长沙 410078；中南大学湘雅医院，教育部癌变与侵袭原理重点实验室，长沙 410078,中南大学湘雅医学院附属肿瘤医院，湖南省肿瘤医院，长沙 410013；中南大学肿瘤研究所，卫生部癌变原理重点实验室，长沙 410078；中南大学湘雅医院，教育部癌变与侵袭原理重点实验室，长沙 410078,中南大学湘雅医学院附属肿瘤医院，湖南省肿瘤医院，长沙 410013；中南大学肿瘤研究所，卫生部癌变原理重点实验室，长沙 410078；中南大学湘雅医院，教育部癌变与侵袭原理重点实验室，长沙 410078,中南大学湘雅医学院附属肿瘤医院，湖南省肿瘤医院，长沙 410013；中南大学肿瘤研究所，卫生部癌变原理重点实验室，长沙 410078；中南大学湘雅医院，教育部癌变与侵袭原理重点实验室，长沙 410078,中南大学湘雅医学院附属肿瘤医院，湖南省肿瘤医院，长沙 410013；中南大学肿瘤研究所，卫生部癌变原理重点实验室，长沙 410078；中南大学湘雅医院，教育部癌变与侵袭原理重点实验室，长沙 410078,中南大学湘雅医学院附属肿瘤医院，湖南省肿瘤医院，长沙 410013；中南大学肿瘤研究所，卫生部癌变原理重点实验室，长沙 410078；中南大学湘雅二医院，长沙 410011
基金项目：国家自然科学基金(81372907, 81472531, 81572787, 81672683, 81672993)和湖南省自然科学基金(2015JJ1022)资助项目
摘    要：长链非编码RNA在调节细胞的生长、分化及其他生物学过程中具有重要作用,且与恶性肿瘤等常见疾病密切相关.人类长链非编码RNA PVT1的编码基因由于位于染色体8q24这一脆性位点且临近癌基因MYC而受到广泛关注.浆细胞瘤可变异位基因1(PVT1)在多种肿瘤中高表达,是潜在的癌基因;PVT1也能因染色体断裂重排而与其他基因形成新的融合基因影响恶性肿瘤的表型;PVT1还可与MYC基因相互作用,通过多种途径参与恶性肿瘤细胞的增殖、凋亡等调控.本文对PVT1在恶性肿瘤发生发展中的作用及其机制进行综述.
关 键 词：恶性肿瘤，长链非编码RNA，PVT1，MYC
收稿时间：2016/11/14 0:00:00
修稿时间：2017/9/14 0:00:00

The Role and Mechanism of PVT1 in Promoting Human Cancer Progression
HE Yi,WEI Fang,ZHANG Shan-Shan,GONG Zhao-Jian,GUO Can,LI Xia-Yu,LI Xiao-Ling,ZHOU Ming,XIONG Wei,LI Gui-Yuan,ZENG Zhao-Yang and SHI Lei.The Role and Mechanism of PVT1 in Promoting Human Cancer Progression[J].Progress In Biochemistry and Biophysics,2017,44(11):981-989.
Authors:HE Yi  WEI Fang  ZHANG Shan-Shan  GONG Zhao-Jian  GUO Can  LI Xia-Yu  LI Xiao-Ling  ZHOU Ming  XIONG Wei  LI Gui-Yuan  ZENG Zhao-Yang and SHI Lei
Institution:Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China; Key Laboratory of Carcinogenesis of Ministry of Health, Cancer Research Institute, Central South University, Changsha 410078, China; Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Xiangya Hospital, Central South University, Changsha 410078, China,Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China; Key Laboratory of Carcinogenesis of Ministry of Health, Cancer Research Institute, Central South University, Changsha 410078, China; Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Xiangya Hospital, Central South University, Changsha 410078, China,Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Xiangya Hospital, Central South University, Changsha 410078, China,Key Laboratory of Carcinogenesis of Ministry of Health, Cancer Research Institute, Central South University, Changsha 410078, China; The Second Xiangya Hospital, Central South University, Changsha 410011, China,Key Laboratory of Carcinogenesis of Ministry of Health, Cancer Research Institute, Central South University, Changsha 410078, China; Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Xiangya Hospital, Central South University, Changsha 410078, China,Hunan Key Laboratory of Nonresolving Inflammation and Cancer, The Third Xiangya Hospital, Central South University, Changsha 410013, China,Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China; Key Laboratory of Carcinogenesis of Ministry of Health, Cancer Research Institute, Central South University, Changsha 410078, China; Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Xiangya Hospital, Central South University, Changsha 410078, China,Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China; Key Laboratory of Carcinogenesis of Ministry of Health, Cancer Research Institute, Central South University, Changsha 410078, China; Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Xiangya Hospital, Central South University, Changsha 410078, China,Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China; Key Laboratory of Carcinogenesis of Ministry of Health, Cancer Research Institute, Central South University, Changsha 410078, China; Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Xiangya Hospital, Central South University, Changsha 410078, China,Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China; Key Laboratory of Carcinogenesis of Ministry of Health, Cancer Research Institute, Central South University, Changsha 410078, China; Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Xiangya Hospital, Central South University, Changsha 410078, China,Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China; Key Laboratory of Carcinogenesis of Ministry of Health, Cancer Research Institute, Central South University, Changsha 410078, China; Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Xiangya Hospital, Central South University, Changsha 410078, China and Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China; Key Laboratory of Carcinogenesis of Ministry of Health, Cancer Research Institute, Central South University, Changsha 410078, China; The Second Xiangya Hospital, Central South University, Changsha 410011, China
Abstract:In recent years, long non-coding RNA is found to play an important role in the regulation of cell growth, differentiation and other biological functions, and is closely related to the occurrence and development of cancer. The long non-coding RNA gene, PVT1, located in the fragile chromosome 8q24 region has been widely concerned. LncRNA PVT1 is highly expresses in many types of cancer, and act as potential oncogene. It is commonly to form new fusion gene by chromosome break, and translocation, and regulation of tumor cell function; it also interact with MYC and participate in tumor cell proliferation, apoptosis by multiple pathways. However, the specific molecular mechanisms that occur in the development of cancer still need further research. In this paper, we summarized the features, functions and roles of PVT1 in human cancer.
Keywords:cancer  long non-coding RNA  PVT1  MYC
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