Damipipecolin and damituricin, novel bioactive bromopyrrole alkaloids from the Mediterranean sponge Axinella damicornis |
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Authors: | Aiello Anna Fattorusso Ernesto Giordano Antonella Menna Marialuisa Müller Werner E G Perović-Ottstadt Sanja Schröder Heinz C |
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Institution: | Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli Federico II, via D Montesano 49, Napoli, Italy. |
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Abstract: | Two new bromopyrrole alkaloids, damipipecolin (1) and damituricin (2), have been isolated from the Mediterranean sponge Axinella damicornis, and their structures established through spectroscopic methods. Compounds 1 and 2 extend the structural variety of the so far known pyrrole alkaloids; in these compounds, the 4-bromopyrrole 2-carboxylic acid is directly condensed with a non-protein cyclic alpha-amino acid, the (2R, 4R)-trans-4-hydroxypipecolic acid and (2R, 4R)-cis-N,N'-dimethyl-4-hydroxyproline (D-turicine) in 1 and 2, respectively. Compounds 1 and 2 were found to display a modulating effect of the serotonin receptor activity in vitro. |
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