| 电穿孔下分子型药物透皮扩散的一类数学模型 |
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| 引用本文： | 吴建军.电穿孔下分子型药物透皮扩散的一类数学模型[J].生物物理学报,2001,17(3):592-598. |
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| 作者姓名： | 吴建军 |
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| 作者单位： | 浙江大学理学院数学系 |
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| 基金项目： | 国家自然科学基金资助项目(编号39670857) |
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| 摘 要： | 针对电穿孔可致使皮肤产生水性新通道的现象，在Fick扩散律和快－慢响应双通道假设下，给出了分子型药物经皮渗透过程的一类数学模型。经计算机模拟，发现其特征与实验数据高度一致，最后简要地讨论了此模垢优缺点和适用性等。
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| 关 键 词： | 电脉冲穿孔 透皮扩散 数学模型 分子型药物 |
| 文章编号： | 1000-6737(2001)03-0592-07 |
| 修稿时间： | 2000年12月19 |
A KIND OF MATHEMATICAL MODEL OF TRANSDERMALPERMEATION OF MOLECULAR DRUG THROUGH ELECTROPORATION |
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| WU Jian-jun.A KIND OF MATHEMATICAL MODEL OF TRANSDERMALPERMEATION OF MOLECULAR DRUG THROUGH ELECTROPORATION[J].Acta Biophysica Sinica,2001,17(3):592-598. |
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| Authors: | WU Jian-jun |
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| Abstract: | A kind of mathematical model of transdermal diffusion of molecular drug through aqueous pores caused by electroporation is given. The model consists of Fick's diffusion law with quick and slow two respondences separately. By computer simulation,it is found that the characteristic is highly consistent with that of a lot of experiment data. Finally, advantages and disadvantages, as concerned with application of the model are discussed briefly. |
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| Keywords: | Electroporation Transdermal diffusion Mathematical model Molecular drug |
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