Isolation and characterization of a neurotoxin from Vipera palestinae venom |
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| Affiliation: | 1. The Rogoff-Wellcome Medical Research Institute, Tel Aviv University, Israel;2. Beilinson Medical Center, Petah-Tikva, Israel;3. Section of Chemical Immunology, The Weizmann Institute of Science Rehovoth Israel;1. School of Information Engineering, East China Jiaotong University, Nanchang, China;2. School of Software, East China Jiaotong University, Nanchang, China;1. Social Perception and Evaluation Laboratory, New York University, NY 10003, USA;2. Social and Organizational Psychology Institute, Leiden University, The Netherlands;1. GIRAT: Grupo de Investigación en Reumatología, Autoimunidad y Medicina Traslacional, Fundación Valle Del Lili and Universidad Icesi, Cali, Colombia;2. Fundación Valle Del Lili, Rheumatology Unit, Cra 98 No. 18 - 49, Cali, 760032, Colombia;3. Department of Physiological Sciences, Department of Health Sciences, Universidad Del Valle, Cali, Colombia;4. Department of Cardiology, Clínica Medellín, Medellín, Colombia;1. Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, Mexico;2. Department of Biology, University of South Alabama, 5871 USA Dr. N, Mobile, AL, 36688, USA;3. Facultad Ciencias Biológicas, Universidad Juárez del Estado de Durango, Av. Universidad s/n. Fracc. Filadelfia, C.P. 35010, Gómez Palacio, Dgo, Mexico;4. Laboratorio de Venómica Evolutiva y Traslacional, Instituto de Biomedicina de Valencia, Consejo Superior de Investigaciones Científicas, Jaime Roig 11, 46010, Valencia, Spain;5. Herp.mx A.C, Villa del Álvarez, Colima, Mexico;6. Department of Biological Sciences and Department of Forestry, and Environmental Conservation, Clemson University, 190 Collings St. Clemson, SC, 29631, USA;7. Unidad Académica de Ciencias Biológicas, Universidad Autónoma de Zacatecas, Edificio de Biología Campus II Ave. Preparatoria S/N, Col. Agronómica, 98066, ZacatecasZacatecas, Mexico;8. Hospital General Norberto Treviño Zapata, Ciudad Victoria, Tamaulipas, Mexico |
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| Abstract: | A neurotoxic protein, denoted viperotoxin, was isolated from the venom of Vipera palestinae. Viporotoxin is homogeneous by ultracentrifugal, electrophoretic and immunochemical criteria. It contains 108 amino acid residues and has a molecular weight of about 11600 (ultracentrifuge). Viperotoxin is composed of one polypeptide chain cross-linked intramolecularly by three disulfide bridges. Lysine is in the amino-terminal position, and proline in the carboxy-terminal position of the viperotoxin chain. |
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