Synthesis and in vitro cytotoxicity of novel long chain busulphan analogues |
| |
| Authors: | Kokotos G Constantinou-Kokotou V Padrón J M Peters G J |
| |
| Affiliation: | Department of Chemistry, University of Athens, Greece. gkokotos@cc.uoa.gr |
| |
| Abstract: | Two novel long chain alkanediol dimethanesulphonates, analogues of busulphan, were synthesized. Their in vitro cytotoxicity was evaluated against six solid tumor cell lines (A2780, H322, LL, WiDr, C26-10 and UMSCC-22B). 2-Tetradecylbutane-1,4-diol dimethanesulphonate was proved to be the most active compound exhibiting IC50 values between 20.82 and 26.36 microM. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
