Herpes-simplex-virus-specific,H-2Dk-restricted T lymphocytes bear receptors for H-2Dd alloantigen |
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Authors: | Klaus Pfizenmaier Hubertus Stockinger Martin Röllinghoff Herman Wagner |
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Institution: | 1. The Institute for Medical Microbiology, Johannes Gutenberg University, D-6500, Mainz, Augustusplatz, Germany
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Abstract: | Cytotoxic T lymphocytes generated in the course of an HSV-infection of CBA (H-2 k ) mice not only lyse syngeneic, virus-infected target cells but also cross-react with noninfected target cells expressing the Dd alloantigen. On the effector cell level, this alloreactivity is mediated by virus-specific CTL's that are restricted to H-2Dk determinants. On the prekiller cell level, the anti-HSV-reactive T cells exhibiting cross-reactivity for Dd alloantigen could be positively selected on H-2d spleen-cell monolayers. After differentiation into cytolytic effector cells, target cells expressing Dd alloantigens and syngeneic HSV-infected target were lysed with equal efficiency. The results imply that the phenomenon of H-2-restricted versus nonrestricted T-cell reactivity is not due to distinct T-cell subsets, but rather is dependent on the antigeneic determinants recognized. |
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