ReplicationDomain: a visualization tool and comparative database for genome-wide replication timing data |
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Authors: | Nodin Weddington Alexander Stuy Ichiro Hiratani Tyrone Ryba Tomoki Yokochi David M Gilbert |
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Institution: | (1) Department of Biological Sciences, Florida State University, Tallahassee, Florida 32306, USA |
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Abstract: | Background Eukaryotic DNA replication is regulated at the level of large chromosomal domains (0.5–5 megabases in mammals) within which
replicons are activated relatively synchronously. These domains replicate in a specific temporal order during S-phase and
our genome-wide analyses of replication timing have demonstrated that this temporal order of domain replication is a stable
property of specific cell types. |
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