The Gene Encoding Protein Kinase SEK1 Maps to Mouse Chromosome 11 and Human Chromosome 17 |
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| Authors: | Robert A White Rowland T Hughes Linda R Adkison Gail Bruns Leonard I Zon |
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| Institution: | aSection of Genetics, Children's Mercy Hospital, UMKC School of Medicine, Kansas City, Missouri, 64108;bDivision of Hematology/Oncology, Howard Hughes Medical Institute, Children's Hospital and Dana Farber Cancer Institute;dGenetics Division, Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Enders 650, Boston, Massachusetts, 02115;cDivision of Biomedical Sciences, Mercer University School of Medicine, Macon, Georgia, 31207 |
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| Abstract: | We report the mapping of the human and mouse genes encoding SEK1 (SAPK/ERK kinase-1), a newly identified protein kinase that is a potent physiological activator of the stress-activated protein kinases. The human SERK1 gene was assigned to human chromosome 17 using genomic DNAs from human–rodent somatic cell hybrid lines. A specific human PCR product was observed solely in the somatic cell line containing human chromosome 17. The mouseSerk1gene was mapped to chromosome 11, closely linked toD11Mit4,using genomic DNAs from a (C57BL/6J ×Mus spretus)F1×M. spretusbackcross. |
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