Inhibitors of the cleavage of aclacinomycins |
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| Authors: | U Gräfe K Dornberger W F Fleck G Schumann |
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| Institution: | (1) Central Institute of Microbiology and Experimental Therapy, GDR Academy of Sciences, P.O. Box 73, DDR-6900 Jena, GDR |
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| Abstract: | Summary The reductive cleavage of the aclacinomycins A (I), Y (II), and B (III) by intact mycelia or subcellular fractions of the producer strain S. spec. AM 33352/F43 is suppressed in the presence of uncouplers, complex-forming agents, detergents, and some metal anions such as chromate. Increased concentration of the latter in complete cultures caused rearrangement of I to III. |
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