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The discovery and structure-activity relationships of pyrano[3,4-b]indole-based inhibitors of hepatitis C virus NS5B polymerase |
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| Authors: | Jackson Randy W LaPorte Matthew G Herbertz Torsten Draper Tandy L Gaboury Janet A Rippin Susan R Patel Ravi Chunduru Srinivas K Benetatos Christopher A Young Dorothy C Burns Christopher J Condon Stephen M |
| Institution: | a VenatoRx Pharmaceuticals Inc., 700 Pennsylvania Drive, Exton, PA 19341, USA b University of Pittsburgh, Center for Chemical Methodologies and Library Development, Pittsburgh, PA 15260, USA c TetraLogic Pharmaceuticals, 343 Phoenixville Pike, Malvern, PA 19355, USA d Department of Medicinal Chemistry, ViroPharma Incorporated, 730 Stockton Drive, Exton, PA 19341, USA e Department of Computational Chemistry, ViroPharma Incorporated, 730 Stockton Drive, Exton, PA 19341, USA f Department of Biology, ViroPharma Incorporated, 730 Stockton Drive, Exton, PA 19341, USA |
| Abstract: | We describe the structure-activity relationship of the C7-position of pyrano3,4-b]indole-based inhibitors of HCV NS5B polymerase. Further exploration of the allosteric binding site led to the discovery of the significantly more potent compounds 13 and 14. |
| Keywords: | HCV NS5B polymerase Pyranoindoles |
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