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4,4-Disubstituted cyclohexylamine NK(1) receptor antagonists II |
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| Authors: | Cooper Laura C Carlson Emma J Castro Jose L Chicchi Gary G Dinnell Kevin Di Salvo Jerry Elliott Jason M Hollingworth Gregory J Kurtz Marc M Ridgill Mark P Rycroft Wayne Tsao Kwei-Lan Swain Christopher J |
| Affiliation: | Department of Medicinal Chemistry, Merck Sharp & Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK. laura_cooper@merck.com |
| Abstract: |  A series of novel 4,4-disubstituted cyclohexylamines as NK(1) receptor antagonists is described: modifications to the amine moiety retain NK(1) receptor binding affinity whilst disrupting I(Kr) affinity. |
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