Steroid sulfates in human pregnancy plasma |
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| Authors: | J Sj?vall K Sj?vall R Vihko |
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| Affiliation: | 1. Department of Nuclear Medicine, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China;2. School of Medicine, Tongji University, Shanghai, China;1. Department of Endocrinological Gynecology, Medical University of Silesia, Katowice, Poland;2. Department of Statistics, Department of Instrumental Analysis, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Poland;3. Pathophysiology Unit, Department of Pathophysiology, Medical University of Silesia, Katowice, Poland;4. Health Promotion and Obesity Management Unit, Department of Pathophysiology, Medical University of Silesia, Katowice, Poland;1. Maastricht University, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht 6200MD, the Netherlands;2. Department of Physiology, University of Kentucky College of Medicine, Lexington 40506, KY, USA;3. Department of Internal Medicine, Laboratory Vascular Medicine, Erasmus MC University Medical Center, Rotterdam 3000CA, the Netherlands;4. Department of Organic Chemistry, Slovak University of Technology, Radlinského 9, 81237 Bratislava, Slovak Republic;5. Department of Molecular Cell Biology and Immunology, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam 1007MB, the Netherlands;6. Department of Neurology, University Hospital Bonn, University of Bonn, Bonn D-53127, Germany;7. Laboratory of Protein Phosphorylation and Proteomics, KU Leuven, Leuven 3000, Belgium;8. Laboratory of Lipid Metabolism and Cancer, KU Leuven, Leuven 3000, Belgium;9. Department of Pathology, Maastricht University, Maastricht 6200MD, the Netherlands;10. Veterans Affairs Medical Center, Lexington, KY 40502, USA |
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| Abstract: | ![]()
Steroid “monosulfate” and “disulfate fractions” were obtained from pregnancy plasma by chromatography on Sephadex LH-20. After solvolysis the steroids were studied by gas chromatography-mass spectrometry. 3β-Hydroxy-5α-pregnan-20-one and 5α-pregnane-3β,20α-diol were identified in addition to compounds previously found in plasma from nonpregnant subjects. At least two additional pregnanolone and two pregnanediol isomers were present. The 17β and 17α isomers of androst-5-ene-3β,17-diol were present in about equal amounts in the “disulfate fraction”. The 5α-pregnane derivatives were the major compounds in both “sulfate fractions”. |
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