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| MPTP/MPP+ 诱导神经元凋亡的机制研究 | |
| 引用本文： | 张玉花 蔡蕊 刘江华 朱春雨 解洪荣. MPTP/MPP+ 诱导神经元凋亡的机制研究[J]. 现代生物医学进展, 2011, 11(5): 964-967 |
| 作者姓名： | 张玉花 蔡蕊 刘江华 朱春雨 解洪荣 |
| 作者单位： | 1. 大庆油田总医院CT室,黑龙江,大庆,163001 2. 天津南开华山医院,天津,300000 3. 大庆油田总医院神经内科,黑龙江,大庆,163001 |
| 摘 要： | 1982年人们发现1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)能诱发PD,它的有效成分是1-甲基-4-苯基吡啶离子(MPP+)。目前,MPTP/MPP+广泛的被用作诱导PD实验模型的有效药物,可诱导神经元细胞发生凋亡性死亡。MPTP/MPP+诱导细胞凋亡的机制牵涉Bcl-2、p53、caspase家族、JNK通路、ERK通路和PARP等多种机制,它们共同参与了MPTP/MPP+诱导的细胞凋亡的调控和执行阶段。本文主要综述MPTP/MPP+诱导的神经元细胞凋亡机制。 |
| 关 键 词： | 1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP) 1-甲基-4-苯基吡啶离子(MPP+) 帕金森病(PD) 凋亡 |
The study of MPTP/MPP+-induced apoptosis of neurons |
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| ZHANG Yu-hu,CAI Rui,LIU Jiang-hu,ZHU Chun-yun,XIE Hong-rong. The study of MPTP/MPP+-induced apoptosis of neurons[J]. Progress in Modern Biomedicine, 2011, 11(5): 964-967 | |
| Authors: | ZHANG Yu-hu CAI Rui LIU Jiang-hu ZHU Chun-yun XIE Hong-rong |
| Affiliation: | 1 Department of Computerized Tomography,Daqing Oilfield General Hospital,Heilongjiang,Daqing 163001,China 2 Tianjin nankai huashan hospital,Tianjin city,300000,China;3 Department of Neurology,Daqing Oilfield General Hospital,Heilongjiang,Daqing 163001,China) |
| Abstract: | Since 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its active neurotoxic metabolite 1-Methy l-4-phenyl-pyridinium (MPP+) have been shown to induce PD, people have done lots of research on the neurotoxicity of MPTP/MPP+. So,MPTP/MPP+ has been widely used to be neurotoxin to induce experimental model of PD. MPTP/MPP+ can induce neuronal apoptosisthrough various mechanisms, involving Bcl-2, p53, caspase, JNK pathway, ERK pathway and PARP etc. These mechanismscollaborative participate in the control and performance of neuronal apoptosis induced by MPTP/MPP+. This article mainly review theapoptosis mechanisms induced by MPTP/MPP+. |
| Keywords: | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) 1-methyl-4-phenylpyridinium ion (MPP+) Apoptosis |
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