Geographic differences in the allele frequencies of the human Y-linked tetranucleotide polymorphism DYS19 |
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| Authors: | Fabrício R Santos Tudevdagva Gerelsaikhan Bjamba Munkhtuja Tsendsuren Oyunsuren Jörg T Epplen Sérgio D J Pena |
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| Institution: | (1) Departamento de Bioquímica, Instituto de Ciências Biológicas - UFMG, Caixa Postal 486, 30161-970 Belo Horizonte, MG, Brazil;(2) Academy of Sciences, Institute of Biotechnology, -51 Ulaanbaatar, Mongolia;(3) Molecular Human Genetics, Ruhr-University, D-44780 Bochum, Germany;(4) Núcleo de Genética Médica de Minas Gerais (GENE/MG), 30130-909 Belo Horizonte, Brazil |
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| Abstract: | We have studied the allele frequency distribution of the microsatellite locus DYS 19 in several populations with different geographical origins worldwide. Three new alleles were found. In addition, remarkable geographic and ethnic differences were observed in the allele frequency profiles and DNA marker (gene) diversity among populations and major ethnic groups. Amerindians showed an overwhelming predominance of the A allele, while in Caucasians the B allele was modal, and in Greater Asians and Africans allele C became predominant. Even within these geographic regions there were significant gradients, as exemplified by the decreasing frequency profile of the B allele from Great Britain over Germany to Slovakia. Thus, DYS 19 emerges as a useful tool for studying the structure and dynamics of human populations. |
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