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HLA-E is the ligand for the natural killer cell CD94/NKG2 receptors
Authors:Phillip E. Posch  Francisco Borrego  Andrew G. Brooks  John E. Coligan PhD
Affiliation:(1) Structural Biology Section, National Institute of Allergy and Infectious Disease, National Institutes of Health, Twinbrook II, Rockville, Md., USA;(2) Laboratory of Immunogenetics, NIAID-NIH, Twinbrook II, 20852 Rockville, MD, USA
Abstract:CD94/NKG2 is a recently described receptor present on natural killer (NK) cells and certain T cells that is composed of the CD94 chain covalently associated with a member of the NKG2 family of molecules. Both chains are glycosylated members of the C-type lectin superfamily. The CD94/NKG2 receptors are functionally heterogenous depending on which NKG2 family member is associated with CD94. Initially, it was thought that CD94/NKG2 receptors recognized a broad array of HLA-A, -B and -C (classical), as well as the nonclassical HLA-G, MHC class I molecules. Instead, recent data have suggested that this receptor is specific for HLA-E complexed with a peptide derived from the signal sequence (residues 3–11) of certain classical MHC class I molecules. Position 2 (residue 4) in the signal sequence derived peptides appears pivotal in determining whether the HLA-E/peptide complex confers resistance to NK-mediated lysis. The potential roles that the CD94/NKG2-HLA-E receptor ligand interaction might play in infection and tumor development are discussed.
Keywords:Natural killer cells  HLA-E  CD94  NKG2  Major histocompatibility complex, class I
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