Capsaicin and potassium evoked substance P release from the nucleus tractus solitarius and spinal trigeminal nucleus |
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Authors: | Cinda J Helke David M Jacobowitz Nguyen B Thoa |
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Institution: | 1. Department of Pharmacology, Uniformed Services University, Bethesda, MD, USA;2. Lab of Clinical Science, National Institute of Mental Health, Bethesda, MD, USA |
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Abstract: | The nucleus tractus solitarius and the spinal trigeminal nucleus receive peripheral sensory input from substance P containing afferent nerves. This study demonstrates that depolarization of these nuclei in tissue slices evokes a calcium-dependent efflux of substance P immunoreactivity. Capsaicin (33μM) also elicits substance P release from the nucleus tractus solitarius and spinal trigeminal nucleus but not from the hypothalamus. The occurrence of potassium-stimulated SP release from the two medullary nuclei fulfills one of the criteria for neurotransmitter status. The capsaicin data support the contention that this agent elicits release of substance P from nuclear regions receiving peripheral afferent information in substance P nerves independent of the particular sensory modality served but is ineffective in nonsensory areas. |
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