Expression of dystrophin on the cell surface membrane of intrafusal fibers of human skeletal muscle |
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| Authors: | Hikaru Tanaka Mikiharu Yoshida Tsuneo Ishiguro Chikahiko Eguchi Ikuya Nonaka Eijiro Ozawa |
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| Affiliation: | (1) National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo;(2) Central Research Laboratories, Ajinomoto Co., Inc., Kawasaki, Kanagawa |
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| Abstract: | Summary We examined the morphological expression of dystrophin in the intrafusal muscle fibers in skeletal muscle from normal human and Duchenne muscular dystrophy (DMD) patients, using antisera against the N-terminal and C-terminal regions of dystrophin. The intrafusal fibers of normal muscle express dystrophin on their cell surface membrane, but those of DMD muscle do not.Abbreviation DMD Duchenne muscular dystrophy |
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| Keywords: | Duchenne muscular dystrophy Dystrophin Muscle spindle |
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