Kinetics and mechanism for platination of thione-containing nucleotides and oligonucleotides: evaluation of the salt dependence |
| |
Authors: | Johan Kjellström Sofi K Elmroth |
| |
Institution: | Inorganic Chemistry, Chemical Center, Lund University, P O Box 124, 221 00 Lund, Sweden. |
| |
Abstract: | Reactions of cis-PtCl(NH(3))(CyNH(2))(OH(2))](+) (Cy=cyclohexyl) with thione-containing single-stranded oligonucleotides d(T(8)XT(8)) and d(XT(16)) (X=(s6)I or (s4)U) and the mononucleotides 4-thiouridine ((s4)UMP) and 6-mercaptoinosine ((s6)IMP) have been studied in aqueous solution at pH 4.1. The reaction kinetics was followed using HPLC methodology as a function of ionic strength in the interval 5.0 mM
|
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |