9-[(Hydroxymethyl)phenyl]adenines: new aryladenine substrates of adenosine deaminase |
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| Authors: | Brakta Mohamed Murthy Devangachinta Ellis L'Ouverture Phadtare Shashikant |
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| Affiliation: | College of Pharmacy, Xavier University of Louisiana, New Orleans 70125, USA. |
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| Abstract: | New phenyl adenine compounds 5-7 were synthesized as analogues of adenosine and studied for their adenosine deaminase (ADA) substrate activity. The 9-[(o-hydroxymethyl)phenyl]methyl]adenine 5 and 9-[(m-hydroxymethyl)phenyl]adenine 7 were deaminated by ADA, and 9-[(o-hydroxyethyl)phenyl]adenine 6 was not deaminated up to 7 days. The ADA substrates 5 and 7 were deaminated quantitatively to their inosine analogues in 10 and 6h, respectively. |
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