Association analysis of the INHA gene with litter size in Boer goats |
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| Affiliation: | 1. Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan 430070, PR China;2. Bureau of Animal Husbandry of Shiyan City, Shiyan 442000, PR China;1. Instituto de Telecomunicações, Av. Rovisco Pais, P-1049-001 Lisboa, Portugal;2. Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, P-1049-001 Lisboa, Portugal;1. Departamento de Química de Radiaciones y Radioquímica, Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, Ciudad de México 04510, México;2. Departamento de Ingeniería Molecular de Materiales, Centro de Física Aplicada y Tecnología Avanzada, Universidad Nacional Autónoma de México, Querétaro 76230, México;3. Centro Universitario de Vinculación y Transferencia de Tecnología, Benemérita Universidad Autónoma de Puebla, Puebla 72000, México;1. Frontier Research Institute for Materials Science, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555, Japan;2. Materials R&D Department, R&D Laboratory, Taiyo Yuden Co., Ltd., Takasaki, Gunma 370-3347, Japan;1. Department of Obstetrics and Gynecology, CHA Bundang Medical Center, School of Medicine, CHA University, Seongnam 463-712, South Korea;2. Institute for Clinical Research, CHA Bundang Medical Center, School of Medicine, CHA University, Seongnam 463-712, South Korea;3. Department of Biomedical Science, College of Life Science, CHA University, Seongnam, South Korea;4. Fertility Center of CHA Gangnam Medical Center, CHA University, Seoul 135-081, South Korea;1. State Key Laboratory of Solidification Processing, Northwestern Polytechnical University, Xi’an 710072, PR China;2. School of Mechanical Engineering, Xi’an University of Science and Technology, Xi’an 710072, PR China;2. Hubei Province''s Engineering Research Center in Buffalo Breeding and Products, Wuhan, Hubei, China 430070;3. Department of Veterinary Medicine and Animal Productions, University of Naples “Federico II”, Naples, Italy 80137;4. Department of Agricultural, Food, and Nutritional Sciences, University of Alberta, Edmonton, AB, Canada T6G 2C8 |
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| Abstract: | This study investigated the association between differences in litter size in Boer does, with genetic polymorphisms in the inhibin alpha gene. Our preliminary (n = 209) results found 12 SNPs, including the non-synonymous polymorphisms 911T/C and 946A/C, resulting in corresponding 299V/A and 311T/P amino acid polymorphisms. Of the SNPs, 651A/G was preliminarily suggested as a useful marker for litter size of the second parity in the population studied, showing an overdominance effect. Polymorphisms, sequence, and genotype distributions were also characterized. |
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