The probability with which EMS-initiated mutagenic lesions generate mutations in CHO cells |
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Authors: | J F Aronson T D Stamato |
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Affiliation: | Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104. |
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Abstract: | In this note we distinguish between multiple mutations affecting a given locus which are generated at separate error-prone lesions and multiple independent mutations generated at a single error-prone lesion. We describe a basis for determining the probability with which the latter class of mutations occurs based on the mutant fraction in the progeny and determine an average probability of 0.6 mutations/replication/mutagenic site for those EMS-modified sites which are mutagenic for G6PDH activity in CHO cells. |
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