Unexpected inhibition of S-adenosyl-L-homocysteine hydrolase by a guanosine nucleoside |
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| Authors: | Seley Katherine L Quirk Stephen Salim Samer Zhang Liang Hagos Asmerom |
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| Affiliation: | School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332-0400, USA. katherine.seley@chemistry.gatech.edu |
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| Abstract: | A series of shape-modified flexible nucleosides ('fleximers', 1, 2, and 3) was modeled, synthesized and subsequently assayed against S-adenosyl-L-homocysteine hydrolase (SAHase). No inhibitory activity was observed for the adenosine fleximer, which served as a substrate, but moderate inhibitory activity was exhibited by the guanosine fleximers. This is the first known report of a guanosine nucleoside analogue possessing activity against SAHase. |
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