Studies towards the next generation of antidepressants. Part 1: Indolylcyclohexylamines as potent serotonin reuptake inhibitors. |
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| Authors: | K L Meagher R E Mewshaw D A Evrard P Zhou D L Smith R Scerni T Spangler S Abulhawa X Shi L E Schechter T H Andree |
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| Affiliation: | Global Chemical Sciences and Neuroscience Departments, Wyeth-Ayerst Research Laboratories, CN 8000, NJ 08543-8000, Princeton, USA. |
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| Abstract: | 
A series of indolylcyclohexylamines possessing potent and selective serotonin reuptake inhibition is reported. The most interesting compounds proved to have subnanomolar 5-HT transporter activity, and exhibited moderate 5-HT(1A) affinity. |
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