The Effect of Visual Deprivation on β-Adrenergic Receptors in the Visual Centres of the Rat Brain |
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| Authors: | Reinhard Schliebs Robert D Burgoyne Volker Bigl |
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| Institution: | Paul Flechsig Institute for Brain Research, Department of Neurochemistry, Karl Marx University, Leipzig, G.D.R.;Brain Research Group, Biology Department, Open University, Milton Keynes, U.K. |
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| Abstract: | The levels of binding of 3H]dihydroalprenolol to beta-adrenergic receptors in the visual centres and frontal cortex from brains of control, dark-reared and monocularly deprived rats were compared. Receptor binding is changed in monocularly deprived rats in the lateral geniculate nuclei and superior colliculi of both sides. Scatchard analyses indicated that the changes in the 3H]dihydroalprenolol binding in the lateral geniculate nuclei were due to alterations in both receptor affinity and receptor number. No effect of dark-rearing could be detected. |
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| Keywords: | Visual deprivation Brain regions Development |
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