Antibody-mediated targeting of liposomes to red cells in vivo |
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Authors: | A Singhal C M Gupta |
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Affiliation: | Division of Biochemistry, Central Drug Research Institute, Lucknow-226 001, India |
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Abstract: | Covalent attachment of anti-rat erythrocyte F(ab')2 to liposomes specifically enhanced their binding to rat erythrocytes in vivo and reduced their uptake by the liver. Furthermore, at least 20-30% of the cell-bound liposomes delivered their contents to the cells. Besides, the liposome binding did not affect the survival time of the target cells at least up to 3 h in the blood circulation. These results demonstrate for the first time that liposomes can be successfully targeted to cells other than liver cells in vivo. |
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