Arctigenin Exhibits Relaxation Effect on Bronchus by Affecting Transmembrane Flow of Calcium |
| |
Authors: | Zhenying Zhao Yongqiang Yin Zengyong Wang Runping Fang Hong Wu Min Jiang Gang Bai Guo’an Luo |
| |
Institution: | 1. College of Pharmacy, Nankai University, Weijin Road 94#, Tianjin, 300071, People’s Republic of China 2. Department of Pharmacology, Tianjin Medical University, Qixiangtai Road 22#, Tianjin, 300070, People’s Republic of China 3. Mudanjiang Medical College, Mudanjiang, Heilongjiang, People’s Republic of China
|
| |
Abstract: | Arctigenin, a lignan extract from Arctium lappa (L.), exhibits anti-inflammation, antioxidation, vasodilator effects, etc. However, the effects of arctigenin on bronchus relaxation are not well investigated. This study aimed to investigate how arctigenin regulates bronchus tone and calcium ion (Ca2+) flow. Trachea strips of guinea pigs were prepared for testing the relaxation effect of arctigenin to acetylcholine, histamine, KCl, and CaCl2, respectively. Furthermore, l-type calcium channel currents were detected by patch–clamp, and intracellular Ca2+ concentration was detected by confocal microscopy. The results showed that arctigenin exhibited relaxation effect on tracheae to different constrictors, and this was related to decreasing cytoplasmic Ca2+ concentration by inhibiting Ca2+ influx partly through l-type calcium channel as well as promoting Ca2+ efflux. In summary, this study provides new insight into the mechanisms by which arctigenin exhibits relaxation effect on bronchus and suggests its potential use for airway disease therapy. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|