Cryptosin induces backbone structural changes in cardiac Na+ and K+ dependent adenosinetriphosphatase |
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| Authors: | R R Venkateswara D Dipak J W Banning C S Vaidyanathan |
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| Affiliation: | Department of Biochemistry, Indian Institute of Science, Bangalore. |
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| Abstract: | Cryptosin, a new cardenolide, was found to preferentially bind to Na,K-ATPase enzyme (7), which is believed to be the ouabain binding site on cardiac sarcolemmal membrane. CD spectral studies revealed that cryptosin, in the presence of Na+ and Mg++ ions, bind to Na,K-ATPase and induce a dose-dependent change in the backbone structure of cardiac Na,K-ATPase. |
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