| 组蛋白甲基化及其与肿瘤间的关系 |
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| 引用本文： | Pan H,Luo XG,Guo S,Liu ZP. 组蛋白甲基化及其与肿瘤间的关系[J]. 生理科学进展, 2010, 41(1): 22-26 |
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| 作者姓名： | Pan H Luo XG Guo S Liu ZP |
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| 作者单位： | 1. 夏回族自治区平罗县中医院,宁夏平罗,753400
2. 天津科技大学生物工程学院,天津,300457;天津科技大学工业微生物教育部重点实验室,天津,300457 |
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| 基金项目： | 天津科技大学引进人才科研启动基金资助课题 |
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| 摘 要： | 组蛋白甲基化修饰是表观遗传学的重要研究领域之一,主要可分为精氨酸甲基化和赖氨酸甲基化两种。越来越多的证据表明组蛋白甲基化功能异常与肿瘤的发生发展密切相关,而且这种甲基化修饰过程是可逆的。对组蛋白甲基化的进一步研究,不仅有助于深入了解基因表达、调控、遗传等生理机制,而且对于肿瘤等重大疾病的诊断、防治和预后判断有重要意义。本文对组蛋白甲基转移酶、去甲基化酶及其与肿瘤发生发展的关系予以综述。
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| 关 键 词： | 组蛋白甲基化 表观遗传 肿瘤 |
Histone methylation and its relationship with cancer |
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| Pan Hui,Luo Xue-Gang,Guo Shu,Liu Zhi-Peng. Histone methylation and its relationship with cancer[J]. Progress in Physiological Sciences, 2010, 41(1): 22-26 |
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| Authors: | Pan Hui Luo Xue-Gang Guo Shu Liu Zhi-Peng |
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| Affiliation: | PAN Hui1,LUO Xue-Gang2,3,GUO Shu2,LIU Zhi-Peng2,3 (1Pingluo TCM Hospital,Pingluo 753400,China,2College of Bioengineering,Tianjin University of Science , Technology,Tianjin 300457,3The Key Laboratory of Industrial Microbiology,Ministry of Education,China) |
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| Abstract: | Histone methylation,including arginine methylation and lysine methylation,is one of the important area of epigenetics research. There is growing evidence that the abnormity of histone methylation is closely related to the process of carcinogenesis,and this methylation is a reversible modification process. Further studies on the histone methylation would not only help to better understand the physiological mechanisms of gene expression,regulation and genetics,but also throw light on the research of diagnosis... |
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| Keywords: | histone methyltation epigenetics cancer |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ |
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